Nobutoshi Watari, et al. (1983) 의 데이터를 digitize 해서 이용했습니다. (10 mg/kg)
두 결과가 일치합니다.
BlueBerry (2020/11/13 access)의 output (인쇄):
BlueBerry _ Online NCA Module.pdf
| Parameter | Unit | Value |
|---|---|---|
| C0 | ng⁄mL | 1.648e+4 |
| λZ | ⁄min | 0.03626 |
| Number of points to estimate λZ | 3 | |
| R2 (λZ) | 1.000 | |
| Adjusted R2 (λZ) | 1.000 | |
| t1/2 (ln(2)/λZ) | min | 19.12 |
| AUC | ng⋅min⁄mL | 3.551e+5 |
| AUClast | ng⋅min⁄mL | 2.922e+5 |
| % Extrapolated AUC | % | 17.73 |
| AUMC | ng⋅min2⁄mL | 8.970e+6 |
| AUMClast | ng⋅min2⁄mL | 4.401e+6 |
| % Extrapolated AUMC | % | 50.93 |
| MRT | min | 25.26 |
| CL | mL⁄min⁄kg | 28.16 |
| VSS | mL⁄kg | 711.3 |
WinNonlin 5.0.1 의 output:
Input File: Workbook - [Untitled1]
Date: 11/13/2020
Time: 17:30:06
WINNONLIN NONCOMPARTMENTAL ANALYSIS PROGRAM
Version 5.0.1 Build 200508151751
Core Version 25Apr2005
Settings
--------
Model: Plasma Data, Bolus IV Administration
Number of nonmissing observations: 9
Dose time: 0.00
Dose amount: 10.00
Calculation method: Linear Trapezoidal with Linear Interpolation
Weighting for lambda_z calculations: Uniform weighting
Lambda_z method: Find best fit for lambda_z, Log regression
Summary Table
-------------
Time Conc. Pred. Residual AUC AUMC Weight
min ng/mL ng/mL ng/mL min*ng/mL min*min*ng/mL
-------------------------------------------------------------------------------
0.0000 @ 1.648e+004 0.0000 0.0000
5.000 1.255e+004 7.256e+004 1.568e+005
10.00 9554. 1.278e+005 5.525e+005
15.00 6802. 1.687e+005 1.046e+006
20.00 5608. 1.997e+005 1.582e+006
25.00 4716. 2.255e+005 2.157e+006
30.00 3809. 2.469e+005 2.738e+006
35.00 * 3280. 3280. 0.1001 2.646e+005 3.310e+006 1.000
40.00 * 2736. 2736. -0.1670 2.796e+005 3.871e+006 1.000
45.00 * 2283. 2282. 0.06967 2.922e+005 4.401e+006 1.000
@) Note - the concentration at dose time was added for extrapolation purposes.
*) Starred values were included in the estimation of Lambda_z.
Final Parameters
---------------
Rsq 1.0000
Rsq_adjusted 1.0000
Corr_XY -1.0000
No_points_lambda_z 3
Lambda_z 1/min 0.0363
Lambda_z_lower min 35.0000
Lambda_z_upper min 45.0000
HL_Lambda_z min 19.1151
Tmax min 5.0000
Cmax ng/mL 12546.5290
Cmax_D kg*ng/mL/mg 1254.6529
C0 ng/mL 16477.2454
Tlast min 45.0000
Clast ng/mL 2282.5613
AUClast min*ng/mL 292161.4842
AUCall min*ng/mL 292161.4842
AUCINF_obs min*ng/mL 355108.2861
AUCINF_D_obs min*kg*ng/mL/mg 35510.8286
AUC_%Extrap_obs % 17.7261
AUC_%Back_Ext_obs % 20.4330
Vz_obs mL/kg 776.5875
Cl_obs mL/min/kg 28.1604
AUCINF_pred min*ng/mL 355106.3649
AUCINF_D_pred min*kg*ng/mL/mg 35510.6365
AUC_%Extrap_pred % 17.7256
AUC_%Back_Ext_pred % 20.4332
Vz_pred mL/kg 776.5917
Cl_pred mL/min/kg 28.1606
AUMClast min*min*ng/mL 4401299.6988
AUMCINF_obs min*min*ng/mL 8969806.5354
AUMC_%Extrap_obs % 50.9321
AUMCINF_pred min*min*ng/mL 8969667.1008
AUMC_%Extrap_pred % 50.9313
MRTlast min 15.0646
MRTINF_obs min 25.2594
MRTINF_pred min 25.2591
Vss_obs mL/kg 711.3142
Vss_pred mL/kg 711.3108
