T A Bowdle, et al. (1980) 의 데이터를 digitize 해서 이용했습니다.
두 결과가 일치합니다.
BlueBerry (2020/11/11 access)의 output (인쇄):
BlueBerry _ Online NCA Module.pdf
Pharmacokinetic parameters
| Parameter | Unit | Value |
|---|---|---|
| C0 | μg⁄mL | 17.03 |
| λZ | ⁄min | 0.02158 |
| Number of points to estimate λZ | 7 | |
| R2 (λZ) | 0.9989 | |
| Adjusted R2 (λZ) | 0.9987 | |
| t1/2 (ln(2)/λZ) | min | 32.12 |
| AUC | μg⋅min⁄mL | 596.1 |
| AUClast | μg⋅min⁄mL | 536.2 |
| % Extrapolated AUC | % | 10.05 |
| AUMC | μg⋅min2⁄mL | 2.596e+4 |
| AUMClast | μg⋅min2⁄mL | 1.689e+4 |
| % Extrapolated AUMC | % | 34.93 |
| MRT | min | 43.55 |
| CL | mL⁄min⁄kg | 41.94 |
| VSS | mL⁄kg | 1826 |
WinNonlin 5.0.1 의 output:
Input File: Workbook - [Untitled1]
Date: 11/11/2020
Time: 15:27:30
WINNONLIN NONCOMPARTMENTAL ANALYSIS PROGRAM
Version 5.0.1 Build 200508151751
Core Version 25Apr2005
Settings
--------
Model: Plasma Data, Bolus IV Administration
Number of nonmissing observations: 8
Dose time: 0.00
Dose amount: 25.00
Calculation method: Linear Trapezoidal with Linear Interpolation
Weighting for lambda_z calculations: Uniform weighting
Lambda_z method: Find best fit for lambda_z, Log regression
Summary Table
-------------
Time Conc. Pred. Residual AUC AUMC Weight
min ug/mL ug/mL ug/mL min*ug/mL min*min*ug/mL
-------------------------------------------------------------------------------
0.0000 @ 17.03 0.0000 0.0000
5.000 13.64 76.68 170.6
15.00 * 8.762 8.679 0.08348 188.7 1169. 1.000
30.00 * 6.402 6.279 0.1233 302.4 3595. 1.000
45.00 * 4.462 4.542 -0.08030 383.9 6541. 1.000
60.00 * 3.266 3.286 -0.02045 441.9 9517. 1.000
75.00 * 2.328 2.377 -0.04934 483.8 1.230e+004 1.000
90.00 * 1.681 1.720 -0.03855 513.9 1.474e+004 1.000
105.0 * 1.293 1.244 0.04909 536.2 1.689e+004 1.000
@) Note - the concentration at dose time was added for extrapolation purposes.
*) Starred values were included in the estimation of Lambda_z.
Final Parameters
---------------
Rsq 0.9989
Rsq_adjusted 0.9987
Corr_XY -0.9994
No_points_lambda_z 7
Lambda_z 1/min 0.0216
Lambda_z_lower min 15.0000
Lambda_z_upper min 105.0000
HL_Lambda_z min 32.1172
Tmax min 5.0000
Cmax ug/mL 13.6443
Cmax_D kg*ug/mL/mg 0.5458
C0 ug/mL 17.0264
Tlast min 105.0000
Clast ug/mL 1.2933
AUClast min*ug/mL 536.2028
AUCall min*ug/mL 536.2028
AUCINF_obs min*ug/mL 596.1283
AUCINF_D_obs min*kg*ug/mL/mg 23.8451
AUC_%Extrap_obs % 10.0524
AUC_%Back_Ext_obs % 12.8624
Vz_obs mL/kg 1943.1767
Cl_obs mL/min/kg 41.9373
AUCINF_pred min*ug/mL 593.8537
AUCINF_D_pred min*kg*ug/mL/mg 23.7541
AUC_%Extrap_pred % 9.7079
AUC_%Back_Ext_pred % 12.9117
Vz_pred mL/kg 1950.6195
Cl_pred mL/min/kg 42.0979
AUMClast min*min*ug/mL 16893.3458
AUMCINF_obs min*min*ug/mL 25962.1821
AUMC_%Extrap_obs % 34.9309
AUMCINF_pred min*min*ug/mL 25617.9582
AUMC_%Extrap_pred % 34.0566
MRTlast min 31.5055
MRTINF_obs min 43.5513
MRTINF_pred min 43.1385
Vss_obs mL/kg 1826.4245
Vss_pred mL/kg 1816.0406
